Peer-reviewed veterinary case report
How to treat cryptococcosis in dogs and cats with amphotericin B?
By Malik, R et al.·Published in Australian veterinary journal·1996·Department of Veterinary Clinical Sciences, United Kingdom·View original on PubMed →
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Original publication title: Combination chemotherapy of canine and feline cryptococcosis using subcutaneously administered amphotericin B.
Plain-English summary
Three dogs and three cats were treated for cryptococcosis, a fungal infection, using a combination of chemotherapy that included a medication called amphotericin B. The treatment involved giving amphotericin B through subcutaneous infusions, which means it was injected under the skin, making it easier and more comfortable for the pets. The animals received this treatment two to three times a week for several months, and all of them were cured of the infection. This method was well tolerated, allowing for effective doses without causing significant side effects.
People also search for: dog cryptococcosis treatment · cat fungal infection cure · amphotericin B for pets
Abstract
Six cases (3 cats, 3 dogs) of cryptococcosis were cured using combination chemotherapy that included amphotericin B. We developed a simple, practical and inexpensive method of administering amphotericin B as a subcutaneous infusion during the treatment of these patients. For this, the calculated dose of amphotericin B (0.5 to 0.8 mg/kg) was added to 400 mL, for cats, or to 500 mL, for dogs, of 0.45% saline containing 2.5% dextrose. These amounts were given subcutaneously 2 or 3 times weekly over several months, to a total cumulative dose of 8 to 26 mg/kg body weight. Subcutaneous infusions were generally well tolerated by the animals, although concentrations of amphotericin B in excess of 20 mg/L resulted in local irritation. This protocol enabled the administration of larger, and thus more effective, quantities of amphotericin B without producing marked azotaemia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8660225/