Peer-reviewed veterinary case report
Combination chemo with vincristine, cyclophosphamide, prednisone puts
By Cohen, Hilliard et al.·Published in American Journal of Veterinary Research·1975·From the Pathology Research Laboratory (Cohen, Schmidt, and Palmer) and the Surgical Research Laboratory (Lucas), Veterans Administration Hospital, 4801 Linwood Blvd, Kansas City, Mo 64128; and the Department of Pathology (Cohen), University of Kansas Medical Center, Kansas City, Ks 66103.·View original on Crossref →
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Original publication title: Combination Chemotherapy with Vincristine, Cyclophosphamide, and Prednisone Producing Long-Term Remission of a Transplanted Canine Lymphoma
- Species:
- dog
Plain-English summary
Three neonatal puppies developed lymphoma after being injected with cancer cells. After about three weeks, three of the puppies began a chemotherapy treatment that included vincristine, cyclophosphamide, and prednisone. Within two to three weeks of starting the treatment, the lymphoma symptoms disappeared, and the puppies remained healthy for nearly two years afterward. In contrast, the puppies that did not receive treatment sadly passed away within a few months. This suggests that combination chemotherapy can effectively treat lymphoma in dogs.
People also search for: puppy lymphoma treatment · vincristine for dogs · canine cancer chemotherapy options
Abstract
SUMMARY Lymphoma developed in 6 neonatal pups inoculated with 1.0 to 2.06 × 109 cells of the 2nd in vivo passage of a canine lymphoma. Three to 4 weeks later (or 8 weeks after the pups had been inoculated), 3 of the 6 pups were started on a chemotherapeutic regimen consisting of vincristine, prednisone, and cyclophosphamide. Twelve to 19 days after combination chemotherapy was started, clinically evident lymphoma disappeared in the 3 pups. Period of treatment was 49 to 84 days. The dogs remained healthy and lymphoma was in complete remission approximately 2 years later. The 3 nontreated pups, used as controls, died of generalized lymphoma 45 to 86 days after inoculation. Seemingly, chemotherapy eradicated the bulk of the tumor, and the host immune response was capable of eliminating residual neoplastic cells. Also, transplanted canine lymphoma seems amenable to treatment and may be curable with combination chemotherapy—thus possibly serving as an experimental therapeutic model.
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Search related cases →Original publication on Crossref: https://doi.org/10.2460/ajvr.1975.36.10.1483