Peer-reviewed veterinary case report
Radiation and chemo help two dogs with relapsed lymphoma
By S. Goto et al.·Published in Journal of Veterinary Medical Science·2025·View original on Semantic Scholar →
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Original publication title: Combined half-body irradiation and chemotherapy for two dogs with relapsed high-grade B-cell lymphoma
- Species:
- dog
Plain-English summary
Two dogs with high-grade B-cell lymphoma relapsed just three months after finishing a six-month chemotherapy treatment. They were treated again with the same chemotherapy drugs and went into complete remission before receiving half-body radiation therapy. While the radiation caused some serious side effects, both dogs have remained in remission for over a year and a half since their relapse. This suggests that combining radiation with chemotherapy can be effective for dogs with relapsed lymphoma.
People also search for: dog lymphoma treatment · half-body radiation for dogs · dog cancer chemotherapy side effects
Abstract
This report describes two dogs with high-grade multicentric B-cell lymphoma that relapsed 3 months after completing a 6-month-long chemotherapy regimen with L-asparaginase, cyclophosphamide, doxorubicin, vincristine, and prednisolone (L-CHOP). Both were re-treated with L-CHOP, achieving complete remission (CR) before undergoing sequential half-body irradiation (HBI; 6 Gy per fraction to cranial and caudal body, 2 weeks apart). Caudal HBI caused grade 3 gastrointestinal toxicity in both dogs and grade 3 thrombocytopenia in one; however, both remain in CR at the time of writing this report (i.e., 483 and 490 days post-relapse). These findings suggest that combining HBI with chemotherapy may offer benefits in relapsed canine lymphoma, especially when dogs are in CR at the time of HBI.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/41183984