Peer-reviewed veterinary case report
Radiation and chemo used for relapsed lymphoma in two dogs
By Goto, Sho et al.·Published in The Journal of veterinary medical science·2026·Morita Animal Hospital, Japan·View original on PubMed →
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Original publication title: Combined half-body irradiation and chemotherapy for two dogs with relapsed high-grade B-cell lymphoma.
- Species:
- dog
Plain-English summary
Two dogs with high-grade B-cell lymphoma relapsed just three months after finishing a six-month chemotherapy treatment. They were given the same chemotherapy again and went into complete remission before receiving half-body radiation therapy. While the radiation caused some serious side effects, both dogs have remained cancer-free for over a year and a half since their relapse. This suggests that combining radiation with chemotherapy can be effective for dogs with relapsed lymphoma.
People also search for: dog lymphoma treatment options · half-body radiation for dogs · dog cancer remission after chemotherapy
Abstract
This report describes two dogs with high-grade multicentric B-cell lymphoma that relapsed 3 months after completing a 6-month-long chemotherapy regimen with L-asparaginase, cyclophosphamide, doxorubicin, vincristine, and prednisolone (L-CHOP). Both were re-treated with L-CHOP, achieving complete remission (CR) before undergoing sequential half-body irradiation (HBI; 6 Gy per fraction to cranial and caudal body, 2 weeks apart). Caudal HBI caused grade 3 gastrointestinal toxicity in both dogs and grade 3 thrombocytopenia in one; however, both remain in CR at the time of writing this report (i.e., 483 and 490 days post-relapse). These findings suggest that combining HBI with chemotherapy may offer benefits in relapsed canine lymphoma, especially when dogs are in CR at the time of HBI.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41183984/