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Peer-reviewed veterinary case report

Cat vomiting and weight loss from gastrinoma treated with surgery

By Myers-Nodes, J & Mazepa, A S W·Published in The Journal of small animal practice·2022·BluePearl Veterinary Partners, United States·View original on PubMed

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Original publication title: Combined surgical and medical management of a cat with gastrinoma.

Species:
cat

Plain-English summary

A 12-year-old spayed female cat was brought to the vet for vomiting, not eating, and losing weight. The vet found she was lethargic and dehydrated, and imaging showed a mass in her intestine. After surgery to remove the mass and a small pancreatic nodule, the nodule was confirmed to be a gastrinoma (a type of tumor that produces excess gastrin). She was treated with omeprazole and toceranib, but the toceranib was stopped after 8 weeks due to decreased appetite. The cat has been doing well on omeprazole alone and has lived more than 35 months since her diagnosis.

People also search for: cat vomiting and weight loss · cat gastrinoma treatment · cat not eating after surgery · long-term care for cat with tumor

Abstract

Gastrinomas are gastrin-secreting pancreatic tumours rarely diagnosed in cats. A 12-year-old female spayed cat was presented for vomiting, anorexia and weight loss. Physical exam revealed lethargy, dehydration and thin body condition. Pertinent laboratory abnormalities included a mild mature neutrophilia and borderline hypoalbuminaemia. Imaging of the abdomen revealed a mass-like change to the proximal duodenum. Exploratory laparotomy was performed, and the duodenal mass along with a 3-mm pancreatic nodule was removed. Immunohistochemical staining of the pancreatic nodule confirmed a gastrinoma. Following surgery, treatment was initiated with omeprazole and toceranib. Toceranib was discontinued after 8 weeks due to hyporexia. The patient was continued on omeprazole long term and has survived more than 35 months since diagnosis. Little information regarding treatment and prognosis for feline gastrinomas is available. In this case report, long-term survival was achieved with a combined surgical and medical approach using omeprazole and toceranib.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35067928/