Peer-reviewed veterinary case report
Effects of IscM and IscQu extracts on cat oral cancer cells
By Cakiroglu, Huseyin et al.·Published in Frontiers in veterinary science·2025·Sakarya University·View original on PubMed →
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Original publication title: Comparative analysis of IscM and IscQu in feline oral squamous cell carcinoma treatment: cytotoxic and apoptotic insights.
- Species:
- cat
Plain-English summary
A cat with oral squamous cell carcinoma (a type of aggressive mouth cancer) was studied to see how two extracts, IscM and IscQu, could help treat this condition. Both extracts were found to kill cancer cells and stop their growth, with IscQu showing slightly better results. This research suggests that these extracts could be useful as part of a treatment plan for cats suffering from this serious cancer. However, more studies are needed to confirm their effectiveness in real-life situations.
People also search for: cat oral cancer treatment · IscQu for feline cancer · feline squamous cell carcinoma prognosis
Abstract
BACKROUND: Feline oral squamous cell carcinoma (FOSCC) is the most common malignant oral tumor in cats, characterized by invasive and aggressive behavior regardless of its location. Conventional treatments, including surgery, radiation therapy, and chemotherapy, often yield unsatisfactory outcomes, with tumor progression and tissue destruction frequently leading to euthanasia. In anthroposophical medicine, extracts ofhave been developed as complementary cancer treatments, with Iscador, the oldest and most widely used oncological drug, showing promising anticancer potential. This study investigated, for the first time, the cytotoxic and apoptotic effects of IscM and IscQu, twoextracts, on FOSCC cells. METHODS: Using primary cultures of three FOSCC cell lines, cell viability assays were performed to assess cytotoxicity, and the effects on apoptotic cell death, cell cycle arrest, and cellular and nuclear morphology were evaluated. Additionally, mRNA expression levels ofandwere analyzed. RESULTS: The results revealed that both IscM and IscQu induced apoptotic cell death and promoted cell cycle arrest in all three FOSCC cell lines tested. IscQu exhibited relatively stronger pro-apoptotic effects compared to IscM, although no significant differences were observed among the cell lines. CONCLUSION: These findings suggest thatextracts, particularly IscQu, may exert anti-tumor effects on feline oral squamous cell carcinoma cells.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40575584/