Peer-reviewed veterinary case report
Survivin protein levels in dogs with lymphoma before and after relapse
By Rebhun, R B et al.·Published in Journal of veterinary internal medicine·2008·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Comparative analysis of survivin expression in untreated and relapsed canine lymphoma.
- Species:
- dog
Plain-English summary
A group of 31 dogs with advanced lymphoma (a type of cancer affecting the lymph nodes) was studied to see how a protein called survivin affected their treatment outcomes. The dogs that showed high levels of survivin before starting chemotherapy had a shorter time without disease progression compared to those with lower levels. Specifically, dogs with high survivin levels had an average of 171 days without disease, while those with low levels lasted about 321 days. This suggests that high survivin levels could indicate a higher risk of treatment failure in dogs with this type of lymphoma.
People also search for: dog lymphoma treatment · survivin protein in dogs · canine cancer prognosis · chemotherapy for dog lymphoma · dog lymph node cancer survival rate
Abstract
BACKGROUND: Survivin, a member of the inhibitor of apoptosis protein family, has a dual role in tumor cell proliferative and antiapoptotic pathways. Survivin expression has been shown to be a negative prognostic factor in several cancers of humans, including B-cell non-Hodgkin's lymphoma. HYPOTHESES: High survivin expression will be a negative prognostic factor in dogs with lymphoma (LSA) treated with chemotherapy. In addition, survivin expression will be upregulated in relapsed canine LSA when compared with patient-matched, pretreatment biopsies. ANIMALS: Thirty-one client-owned dogs with stage IIIa or IVa LSA. METHODS: Retrospective evaluation of survivin immunoreactivity was performed on pretreatment lymph node biopsies and patient-matched samples obtained from dogs at relapse after being treated with an abbreviated CHOP-based protocol. RESULTS: In this population of dogs presenting with stage IIIa or IVa B-cell LSA, those dogs that had high survivin immunoreactivity scores had a significantly (P < .01, hazard ratio = 0.30) shorter median disease-free interval than did dogs with low survivin immunoreactivity scores (171 days versus 321 days, respectively). Survivin immunoreactivity was not significantly different in relapsed canine LSA when compared with patient-matched, pretreatment biopsies. CONCLUSIONS AND CLINICAL IMPORTANCE: Survivin expression is a negative prognostic factor that can predict early treatment failure of dogs that present with stage IIIa or IVa, B-cell LSA when treated with a CHOP-based protocol.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18647159/