Peer-reviewed veterinary case report
Intranasal vs injectable vaccines for antibody response in dogs
By Ellis, John A et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2017·Department of Veterinary Microbiology (Ellis, United States·View original on PubMed →
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Original publication title: Comparative efficacy of intranasal and injectable vaccines in stimulating-reactive anamnestic antibody responses in household dogs.
- Species:
- dog
Plain-English summary
A group of 144 adult dogs received either an intranasal or an injectable vaccine to boost their immune response after being vaccinated about a year earlier. After 10 to 14 days, blood and nasal samples showed that both types of vaccines effectively increased antibodies in the dogs. However, the dogs that received the intranasal vaccine had a significantly higher level of a specific antibody in their blood. This suggests that both vaccine types can help strengthen the immune system in dogs that have been previously vaccinated.
People also search for: dog vaccine effectiveness · intranasal vs injectable dog vaccine · boosting dog immunity after vaccination
Abstract
In order to determine the comparative efficacy of injectable and intranasal vaccines to stimulate-reactive anamnestic antibodies, a trial was conducted using 144 adult household dogs of various breeds and ages, which had been previously administered intranasalvaccine approximately 12 months before enrollment. Dogs were randomized into 2 groups and blood, nasal swabs, and pharyngeal swabs were collected prior to the administration of single componentvaccines intranasally or parenterally. Ten to 14 days later all dogs were resampled to measure changes in systemic and local antibody toThere were no differences in the changes in-reactive serum IgG and nasal IgA between the groups, whereas intranasally vaccinated dogs had significantly higher-reactive serum IgA. These data indicate that both of the current generation of intranasal (modified-live) and injectable (acellular)vaccines can stimulate anamnestic local and systemic antibody responses in previously vaccinated,-seropositive adult household dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28761185/