Comparative efficacy of intranasal and injectable vaccines in stimulating-reactive anamnestic antibody responses in household dogs.

Abstract

In order to determine the comparative efficacy of injectable and intranasal vaccines to stimulate-reactive anamnestic antibodies, a trial was conducted using 144 adult household dogs of various breeds and ages, which had been previously administered intranasalvaccine approximately 12 months before enrollment. Dogs were randomized into 2 groups and blood, nasal swabs, and pharyngeal swabs were collected prior to the administration of single componentvaccines intranasally or parenterally. Ten to 14 days later all dogs were resampled to measure changes in systemic and local antibody toThere were no differences in the changes in-reactive serum IgG and nasal IgA between the groups, whereas intranasally vaccinated dogs had significantly higher-reactive serum IgA. These data indicate that both of the current generation of intranasal (modified-live) and injectable (acellular)vaccines can stimulate anamnestic local and systemic antibody responses in previously vaccinated,-seropositive adult household dogs.