Peer-reviewed veterinary case report
Accuracy of SNAP 4Dx test for detecting dog tick infections in Hong
By Wong, Samson S Y et al.·Published in Vector borne and zoonotic diseases (Larchmont, N.Y.)·2011·Department of Microbiology·View original on PubMed →
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Original publication title: Comparative evaluation of a point-of-care immunochromatographic test SNAP 4Dx with molecular detection tests for vector-borne canine pathogens in Hong Kong.
- Species:
- dog
Plain-English summary
A study looked at how well a quick test for certain dog diseases compared to a more detailed lab test. They tested 100 pet dogs and 100 stray dogs, finding that both tests agreed on most results, but there were some differences, especially with infections like Ehrlichia and Anaplasma. The quick test didn't check for some common infections like babesiosis, which was found in many of the dogs. Overall, the quick test was helpful, but pet owners should be aware it might miss some infections.
People also search for: dog blood test for Ehrlichia · quick test for dog diseases · babesiosis in dogs symptoms
Abstract
There are no comprehensive studies on the performance of commonly used point-of-care diagnostic enzyme immunoassay for common arthropod-borne canine pathogens. A comparative evaluation of an immunochromatographic test for these infections with a comprehensive polymerase chain reaction (PCR) test panel was performed on 100 pet dogs and 100 stray dogs without obvious clinical symptoms. Of the 162 positive test results from both immunochromatographic test and PCR, there was 85.2% concordance. The 24 discordant results between serology and PCR occurred in tests involving Ehrlichia canis (14) and Anaplasma platys (10), which may be related to the time of infection. No positive cases of borreliosis or rickettsiosis were detected. One important limitation of the immunochromatographic test was its lack of testing for babesiosis and hepatozoonosis. The former is the most prevalent arthropod-borne canine infection in our cohort (41%). Coinfections were found in 19% stray dogs and 6% of pet dogs with both tests (p < 0.01). Seventeen and 8 samples from stray and pet dogs, respectively, were initially positive in the PCR test for Ehrlichia. However, on sequencing of the PCR amplicon, 10 from stray and 2 from pet dogs were found to be Wolbachia sequences instead, with 100% nucleotide identity to the 16S rRNA sequence of Wolbachia endosymbiont of Dirofilaria immitis. The presence of Wolbachia DNAemia (6%) correlated well with the molecular test and immunochromatographic antigen test for D. immitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21612526/