Peer-reviewed veterinary case report
Imepitoin drug levels after oral vs rectal dosing in healthy dogs
By Martlé, Valentine et al.·Published in Veterinary journal (London, England : 1997)·2020·Small Animal Department·View original on PubMed →
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Original publication title: Comparative pharmacokinetics of imepitoin after oral and rectal administration in healthy dogs.
- Species:
- dog
Plain-English summary
A group of healthy dogs was given a medication called imepitoin, which is often used to help with seizures, either by mouth or rectally to see how well it worked. The results showed that when imepitoin was given rectally, the dogs had lower levels of the medication in their blood compared to when it was given orally. This means that giving imepitoin rectally is not as effective as giving it by mouth.
People also search for: dog seizure medication imepitoin · how to give dog medicine rectally · dog medication absorption differences
Abstract
The purpose of the present study was to investigate if rectal administration of imepitoin in healthy dogs leads to plasma concentrations comparable to those after oral administration. Significantly lower systemic exposure and maximal plasma concentration (C) of imepitoin was achieved after rectal compared to oral administration (P≤0.001). Therefore, this study does not support the rectal administration of imepitoin in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32553240/