Peer-reviewed veterinary case report
Cerebrospinal fluid and blood lactate levels in dogs with brain
By Benedicenti, Leontine et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2018·School of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Comparison between cerebrospinal fluid and serum lactate concentrations in neurologic dogs with and without structural intracranial disease.
- Species:
- dog
Plain-English summary
A group of 24 dogs showing signs of neurological problems, such as seizures or coordination issues, had their blood and cerebrospinal fluid tested after undergoing an MRI of the brain. The study aimed to see if dogs with structural brain disease had higher levels of lactate in their cerebrospinal fluid compared to those without structural issues. However, the results showed no significant difference in lactate levels between the two groups, indicating that lactate levels in the cerebrospinal fluid and blood were similar regardless of the presence of structural brain disease.
People also search for: dog neurological signs · dog MRI results explained · dog cerebrospinal fluid test results
Abstract
The objectives of this study were to investigate the relationship between cerebrospinal fluid lactate and serum concentrations in dogs with clinical signs of central nervous system disease and to establish if cerebrospinal fluid lactate (CSF) concentrations are higher in dogs with structural intracranial disease (Group Pos-MRI) compared to dogs that have clinical signs of intracranial disease but no structural brain disease (Group Neg-MRI) based on magnetic resonance imaging (MRI) findings. Using a prospective study canine blood and cerebrospinal fluid were collected in 24 dogs with neurological signs after undergoing brain MRI. Dogs were divided in 2 groups. No significant difference between serum lactate (1.57 ± 0.9 mmol/L) and CSF lactate concentration (1.34 ± 0.3 mmol/L) was detected. There was a direct correlation between CSF and serum lactate concentration (= 0.731;= 0.01). No significant difference was found in CSF lactate concentration between the 2 groups of dogs (= 0.13).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29755188/