Peer-reviewed veterinary case report
Longer remission in dogs with lymphoma using L-CHOP plus CCNU
By Rassnick, K M et al.·Published in Veterinary and comparative oncology·2010·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Comparison between L-CHOP and an L-CHOP protocol with interposed treatments of CCNU and MOPP (L-CHOP-CCNU-MOPP) for lymphoma in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with lymphoma (a type of cancer) was treated with two different chemotherapy protocols: one standard (L-CHOP) and one that included additional treatments (L-CHOP-CCNU-MOPP). Both treatments had similar success rates in achieving remission, but the dogs receiving the L-CHOP-CCNU-MOPP protocol stayed in remission longer, with an average of about 317 days compared to 298 days for the standard treatment. However, some dogs experienced more side effects, like low white blood cell counts, with the additional treatments. Overall, while the L-CHOP-CCNU-MOPP protocol showed better remission duration, the choice of treatment should be discussed with a veterinarian based on individual circumstances.
People also search for: dog lymphoma treatment options · chemotherapy side effects in dogs · how long do dogs stay in remission from lymphoma
Abstract
An L-CHOP protocol with interposed treatments of CCNU and MOPP (L-CHOP-CCNU-MOPP) was evaluated in 66 dogs with stages III-V lymphoma. Results were compared with a historical group of 71 dogs treated with an L-CHOP protocol. Complete remission (CR) rates (85 and 80%, respectively) did not differ significantly between protocols (P = 0.48). First CR duration for dogs treated with L-CHOP-CCNU-MOPP was significantly longer: median, 317 days; 2-year CR rate, 35% versus median, 298 days; 2-year CR rate, 13%, P = 0.05). For the L-CHOP-CCNU-MOPP protocol, dogs in substage-b had a 4.3 times greater hazard of having a relapse than dogs in substage-a (P = 0.002). Frequency of adverse chemotherapy-associated gastrointestinal effects did not differ between protocols (P = 0.77). Neutropenia (primarily after CCNU) occurred more frequently in dogs treated with L-CHOP-CCNU-MOPP (P < 0.001). In summary, the L-CHOP-CCNU-MOPP protocol showed an improved duration of first CR as compared with an L-CHOP protocol, but the relevance of this finding might be subject to clinical judgement.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21062406/