Peer-reviewed veterinary case report
Survival times in dogs with lymphoma treated by COAP or UW-19
By Hosoya, Kenji et al.·Published in Journal of veterinary internal medicine·2007·Department of Veterinary Clinical Sciences and Veterinary Teaching Hospital, United States·View original on PubMed →
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Original publication title: Comparison of COAP and UW-19 protocols for dogs with multicentric lymphoma.
- Species:
- dog
Plain-English summary
A group of 101 dogs with multicentric lymphoma (a type of cancer) were treated with two different chemotherapy protocols to see which one worked better. One group received the COAP protocol, while the other received the UW-19 protocol. The dogs on the COAP protocol had a shorter first remission period but a slightly longer median survival time compared to the UW-19 group. However, the UW-19 group experienced more severe side effects, like low white blood cell counts and gastrointestinal issues. Overall, the study suggests that the COAP protocol may be safer, even if it leads to a quicker relapse.
People also search for: dog lymphoma treatment · COAP vs UW-19 chemotherapy for dogs · side effects of lymphoma treatment in dogs
Abstract
BACKGROUND: Various chemotherapy protocols for treating lymphoma in dogs have been published; however, comparison of protocols from different studies is difficult, especially when evaluating survival time and toxicoses. HYPOTHESIS: The choice of COAP (C, cyclophosphamide; O, vincristine; A, cytosine arabinoside; P, prednisone) and a modified University of Wisconsin 19-week (UW-19) induction protocol has no influence on overall survival times in dogs with lymphoma. ANIMALS: One hundred and one dogs with multicentric lymphoma. METHODS: Retrospective study (2001-2006). Dogs induced with either an 8-week COP-based protocol (C, cyclophosphamide; O, vincristine; and P, prednisone) with maintenance therapy (COAP group) or a 19-week CHOP (C, cyclophosphamide; H, doxorubicin; O, vincristine; and P, prednisone) based protocol (UW-19 group) were compared in terms of the duration of first remission, survival time, toxicoses, and cost. RESULTS: There were 71 dogs in the COAP group and 30 dogs in the UW-19 group. Various protocols were used after the first relapse. The median duration of the first remission for the COAP and UW-19 groups were 94 days (range, 6-356 days) and 174 days (28-438 days), respectively (P < .01). The median survival times for dogs in the COAP and UW-19 groups were 309 days (6-620 days) and 275 days (70-1102+ days), respectively (P = .09). Dogs in the COAP group had a hazard ratio of 1.9 (95% CI 1.1-3.4) for death relative to the UW-19 group (P = .03), after controlling for the confounders (World Health Organization clinical stage, age, sex, use of doxorubicin during reinduction). The severity of neutropenia and gastrointestinal toxicoses were significantly higher in the UW-19 group than in the COAP group (P = .01 and P < .01, respectively). CONCLUSION AND CLINICAL IMPORTANCE: Use of a long-term doxorubicin-containing sequential combination chemotherapy protocol is associated with a decreased risk of relapse and death relative to a non-doxorubicin-containing protocol.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18196747/