Peer-reviewed veterinary case report
Radiation treatment options for cats with injection-site sarcoma
By Rossi, Federica et al.·Published in Journal of feline medicine and surgery·2019·1 Veterinary Oncology Centre, Italy·View original on PubMed →
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Original publication title: Comparison of definitive-intent finely fractionated and palliative-intent coarsely fractionated radiotherapy as adjuvant treatment of feline microscopic injection-site sarcoma.
- Species:
- cat
Plain-English summary
A group of cats with injection-site sarcomas, a type of cancer that can develop at vaccination sites, were treated after surgery with two different types of radiation therapy. One group received finely fractionated radiation, while the other received coarsely fractionated radiation. The results showed that cats with their first occurrence of this cancer had a longer time without disease progression when treated with the finely fractionated method, lasting about 1430 days compared to 540 days for the coarsely fractionated group. However, for cats that had multiple surgeries, both treatments showed similar outcomes.
People also search for: cat injection site sarcoma treatment · feline cancer radiation therapy · cat vaccination site tumor prognosis
Abstract
OBJECTIVES: The aim of this retrospective, bi-institutional study was to evaluate the progression-free interval in a cohort of cats with postoperative microscopic injection-site sarcoma (ISS) treated with two different radiotherapy protocols. METHODS: Included in the study were cats with ISSs undergoing macroscopic surgical removal and subsequent electron beam radiotherapy treatment with either a finely fractionated protocol (48 or 52.8 Gy over 4 weeks delivered in 12 or 16 fractions) or a coarsely fractionated protocol (36 Gy over 3 weeks administered in six fractions). Medical records were reviewed and follow-up information was collected. The Kaplan-Meier method and log-rank test were used to compare the progression-free interval (PFI) between the two protocols and to test the influence of many clinical variables. RESULTS: Fifty-nine cats were included; 38 underwent a finely fractionated protocol and 21 a coarsely fractionated protocol. PFI was not significantly different between the two groups. Overall PFI was 2000 days (2000 vs 540 days; P = 0.449). When only first-occurrence cases were included, median PFI was significantly longer in the finely fractionated group compared with the coarsely fractionated group (1430 vs 540 days; P = 0.007). In cats that underwent multiple surgeries PFI was not different between protocols (233 vs 395 days; P = 0.353). CONCLUSIONS AND RELEVANCE: Cats with first-occurrence ISSs appear to benefit from postoperative finely fractionated radiotherapy. The same benefit was not evident in cats that underwent multiple surgeries and we think a coarsely fractionated protocol would be indicated in these cases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29473768/