Peer-reviewed veterinary case report
How well do quick tests find parvovirus antibodies in dogs
By Bergmann, Michèle et al.·Published in Viruses·2020·Clinic of Small Animal Medicine, Germany·View original on PubMed →
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Original publication title: Comparison of Four Commercially Available Point-of-Care Tests to Detect Antibodies against Canine Parvovirus in Dogs.
- Species:
- dog
Plain-English summary
A group of dogs was tested for immunity against canine parvovirus (CPV) using four different quick tests to see which one worked best. The tests showed that most dogs had antibodies against CPV, which means they were likely protected from the virus. The FASTest test was found to be the most sensitive, accurately detecting antibodies in 95% of the dogs, while the CanTiCheck test had the highest specificity, meaning it was good at confirming true positives. Overall, the CanTiCheck test was recommended for its balance of accuracy and ease of use.
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Abstract
Measuring antibodies to evaluate dogs' immunity against canine parvovirus (CPV) is useful to avoid unnecessary re-vaccinations. The study aimed to evaluate the quality and practicability of four point-of-care (POC) tests for detection of anti-CPV antibodies. The sera of 198 client-owned and 43 specific pathogen-free (SPF) dogs were included; virus neutralization was the reference method. Specificity, sensitivity, positive and negative predictive value (PPV and NPV), and overall accuracy (OA) were calculated. Specificity was considered to be the most important indicator for POC test performance. Differences between specificity and sensitivity of POC tests in the sera of all dogs were determined by McNemar, agreement by Cohen's kappa. Prevalence of anti-CPV antibodies in all dogs was 80% (192/241); in the subgroup of client-owned dogs, it was 97% (192/198); and in the subgroup of SPF dogs, it was 0% (0/43). FASTestand CanTiCheckwere easiest to perform. Specificity was highest in the CanTiCheck(overall dogs, 98%; client-owned dogs, 83%; SPF dogs, 100%) and the TiterCHEK(overall dogs, 96%; client-owned dogs, 67%; SPF dogs, 100%); no significant differences in specificity were observed between the ImmunoComb, the TiterCHEK, and the CanTiCheck. Sensitivity was highest in the FASTest(overall dogs, 95%; client-owned dogs, 95%) and the CanTiCheck(overall dogs, 80%; client-owned dogs, 80%); sensitivity of the FASTestwas significantly higher compared to the one of the other three tests (McNemars-value in each comparison: <0.001). CanTiCheckwould be the POC test of choice when considering specificity and practicability. However, differences in the number of false positive results between CanTiCheck, TiterCHEK, and ImmunoCombwere minimal.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33374843/