Peer-reviewed veterinary case report
Serum cytokine differences in dogs with osteosarcoma at diagnosis
By Allende, Carolina et al.·Published in Veterinary immunology and immunopathology·2020·Oregon State University Carlson College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Comparison of serum cytokine concentrations between healthy dogs and canine osteosarcoma patients at the time of diagnosis.
- Species:
- dog
Plain-English summary
A group of dogs with osteosarcoma, a type of bone cancer, had higher levels of certain immune proteins called cytokines in their blood compared to healthy dogs. Specifically, the study found increased amounts of interleukin-8 and interleukin-12p40 in the cancer patients at the time of diagnosis. This information could help veterinarians understand the disease better and may lead to new ways to diagnose and treat osteosarcoma in dogs. Further research could explore how these cytokine levels might be used to improve care for affected pets.
People also search for: dog osteosarcoma symptoms · dog cancer treatment options · high cytokine levels in dogs
Abstract
Systemic immune responses in cancer patients are of tremendous importance, both to advance understanding of disease mechanisms and for development of new diagnostic testing. Minimal published information is available on the systemic cytokine response in canine osteosarcoma (OS) patients. The goal of this study was to investigate serum cytokine alterations present in OS patients at the time of diagnosis. Serum samples from 22 canine OS patients at the time of diagnosis and 18 healthy control dogs were evaluated via multiplex immunoassay for 14 analytes. Significant increases in serum interleukin-8 (IL-8) and interleukin-12p40 (IL-12p40) concentrations were found in OS patients when compared to healthy controls. The results correlate with several published studies on serum cytokine alterations in human OS patients. These data add to the growing body of knowledge on immunologic alterations in OS, including potential immunomodulatory therapy of canine patients, and support future studies on serum cytokine testing to investigate diagnostic and prognostic utility.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32559421/