Comparison of the effects of intranasal and intramuscular administrations of zolazepam-tiletamine combination on intraocular pressure in cats.

Abstract

OBJECTIVE: To determine the effect of intranasal (IN) and intramuscular (IM administration of zolazepam-tiletamine (ZT) combination on intraocular pressure (IOP). ANIMALS STUDIED: Both eyes of 8 clinically normal cats were used. PROCEDURES: The animals received 10 mg/kg dose of ZT combination by IN and IM routes with a 7-day interval between treatments. IOP values were measured at baseline (T0) and at 10, 15, 20, 25, 30, and 45 min in both treatment groups. RESULTS: There were no statistically significant differences between baseline and post-treatment IOP measurements. The IOP did not change over time regardless of administration route. CONCLUSIONS: ZT combination did not have a significant effect on IOP in cats, when administered by IM or IN routes.