Peer-reviewed veterinary case report
Complex polysaccharide deposits in muscle near sarcomas in two dogs
By Valentine, B A et al.·Published in Veterinary pathology·2002·Department of Biomedical Sciences, United States·View original on PubMed →
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Original publication title: Complex polysaccharide inclusions in skeletal muscle adjacent to sarcomas in two dogs.
- Species:
- dog
Plain-English summary
An 8-year-old female Cocker Spaniel and a 7-year-old female Bouvier des Flandres were both found to have unusual material in their skeletal muscles near tumors. The Cocker Spaniel had an osteosarcoma (a type of bone cancer), while the Bouvier had a synovial cell sarcoma (a type of soft tissue cancer). The material found in their muscles was similar to complex polysaccharides, which can accumulate due to various metabolic changes. There was no evidence of a specific metabolic disorder in either dog, indicating that this muscle change can happen in response to different health issues.
People also search for: dog muscle problems · Cocker Spaniel osteosarcoma · Bouvier des Flandres tumor symptoms
Abstract
Inclusions of periodic acid-Schiff-positive, amylase resistant material were found within skeletal muscle fibers adjacent to an osteosarcoma in the proximal femur of an 8-year-old intact female Cocker Spaniel dog (dog No. 1) and adjacent to a synovial cell sarcoma of the stifle joint in a 7-year-old spayed female Bouvier des Flandres dog (dog No. 2). Inclusions were pale blue-gray with hematoxylin and eosin stain and formed irregular inclusions, replacing up to approximately 80% of the fiber diameter. Inclusions from dog No. 2 were of non-membrane-bound granular to filamentous material that occasionally formed discrete, elongate electron-dense masses. The features of these inclusions were similar to those of materials previously described as complex polysaccharide, polyglucosan bodies, amylopectin, and Lafora bodies. Evidence for a generalized metabolic disorder was not found in these two dogs, suggesting that storage of complex polysaccharide can occur as a relatively nonspecific response to metabolic alterations in skeletal muscle in a variety of conditions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12009068/