Peer-reviewed veterinary case report
Dog diagnosed with two types of lymphoma at once
By Matsuyama, Arata et al.·Published in BMC veterinary research·2019·University of Guelph, Canada·View original on PubMed →
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Original publication title: Composite lymphoma of concurrent T zone lymphoma and large cell B cell lymphoma in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old male Mastiff was brought to the vet because he had swollen lymph nodes all over his body. Initially, he was diagnosed with a type of cancer called T zone lymphoma. Thirteen months later, he returned with even more swollen lymph nodes, and tests revealed he had developed a second type of cancer called large B cell lymphoma. Advanced testing confirmed that both types of lymphoma were present at the same time. Unfortunately, the outcome for this dog was not mentioned, but understanding the presence of two different lymphomas can help guide treatment options.
People also search for: dog swollen lymph nodes · Mastiff lymphoma treatment · dog cancer types · lymphadenopathy in dogs
Abstract
BACKGROUND: Evolution of indolent to aggressive lymphoma has been described in dogs but is difficult to distinguish from the de novo development of a second, clonally distinct lymphoma. Differentiation of these scenarios can be aided by next generation sequencing (NGS)-based assessment of clonality of lymphocyte antigen receptor genes. CASE PRESENTATION: An 8-year-old male intact Mastiff presented with generalized lymphadenomegaly was diagnosed with nodal T zone lymphoma (TZL) based on cytology, histopathology, immunohistochemistry and flow cytometry. Thirteen months later, the dog re-presented with progressive lymphadenomegaly, and based on cytology and flow cytometry, a large B cell lymphoma (LBCL) was diagnosed. Sequencing-based clonality testing confirmed the de novo development of a LBCL and the persistence of a TZL. CONCLUSIONS: The occurrence of two distinct lymphoid neoplasms should be considered if patient features and tumor cytomorphology or immunophenotype differ among sequential samples. Sequencing-based clonality testing may provide conclusive evidence of two concurrent and distinct clonal lymphocyte populations, termed most appropriately "composite lymphoma".
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31733649/