Peer-reviewed veterinary case report
CT scan shows brain changes in dog with ceroid lipofuscinosis
By Franks, J N et al.·Published in Journal of the American Animal Hospital Association·1999·Department of Small Animal Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Computed tomographic findings of ceroid lipofuscinosis in a dog.
- Species:
- dog
Plain-English summary
A 2-year-old male border collie was brought in for worsening neurological issues over two months, including blindness, difficulty walking, confusion, and partial seizures. Despite various tests showing normal results, a CT scan of the brain revealed significant changes, leading to a diagnosis of ceroid lipofuscinosis, a serious brain disorder. Unfortunately, due to the poor prognosis, the dog was euthanized. This case highlights the challenges in diagnosing and managing this rare condition in dogs.
People also search for: dog blindness and seizures · border collie neurological problems · ceroid lipofuscinosis in dogs
Abstract
A two-year and seven-month-old, castrated male border collie was presented for a two-month history of progressive neurological signs including blindness, ataxia, dementia, and partial seizures. A complete blood count, serum biochemical profile, urinalysis, thoracic radiographs, and cerebrospinal fluid analysis were within reference ranges. Computed tomography (CT) of the brain showed dilatation of the ventricles and atrophy of the cerebral cortex. A central nervous system (CNS) storage disease was suspected, and the dog was euthanized due to a poor prognosis. Light and electron microscopic examination revealed neuronal degeneration with pigment accumulation in neurons of the CNS, in ganglia of the peripheral nervous system, and in several non-nervous tissues. Ceroid lipofuscinosis was diagnosed based on the microscopic and ultrastructural lesions detected. This is the second report of CT findings in a canine clinical patient with ceroid lipofuscinosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10493420/