Peer-reviewed veterinary case report
Dog with kidney amyloidosis and thymoma dies from heart clot
By Loewen, Jennifer M et al.·Published in Journal of veterinary internal medicine·2018·Department of Veterinary Clinical Sciences·View original on PubMed →
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Original publication title: Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog.
- Species:
- dog
Plain-English summary
A 7-year-old male Weimaraner was brought to the vet because he was not eating, seemed very tired, and was having trouble breathing. Tests showed he had kidney issues and a tumor in his thymus gland, which was surgically removed. Unfortunately, after the surgery, he developed a serious blood clot in his heart and had to be euthanized. This case highlights that dogs with thymoma (a type of tumor) can also have kidney problems, and it's important for vets to check for these issues before surgery.
People also search for: dog not eating lethargy breathing problems · Weimaraner thymoma treatment · kidney disease in dogs symptoms
Abstract
Thymoma-associated nephropathies have been reported in people but not in dogs. In this report, we describe a dog with thymoma and concurrent renal amyloidosis. A 7-year-old castrated male Weimaraner was presented for progressive anorexia, lethargy, and tachypnea. The dog was diagnosed with azotemia, marked proteinuria, and a thymoma that was surgically removed. Postoperatively, the dog developed a large left ventricular thrombus and was euthanized. Necropsy confirmed the presence of a left ventricular thrombus and histopathology revealed renal amyloidosis. We speculate that the renal amyloidosis occurred secondary to the thymoma, with amyloidosis in turn leading to nephrotic syndrome, hypercoagulability, and ventricular thrombosis. This case illustrates the potential for thymoma-associated nephropathies to occur in dogs and that dogs suspected to have thymoma should have a urinalysis and urine protein creatinine ratio performed as part of the pre-surgical database.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29485186/