Peer-reviewed veterinary case report
Congenital nerve sheath tumor causing a mass on a puppy dog's chest
By Cole, Jesse et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2026·Department of Microbiology, United States·View original on PubMed →
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Original publication title: Congenital nerve sheath tumor in a dog.
- Species:
- dog
Plain-English summary
A 5-week-old female Leonberger was brought to the vet because of a mass on her chest that had been there since birth. After a biopsy, the vet found that the mass was a congenital nerve sheath tumor, which is a rare type of tumor in dogs. This tumor was invasive and had specific characteristics that helped confirm the diagnosis. While the tumor is uncommon, the vet can discuss treatment options if the mass causes any issues for the puppy in the future.
People also search for: Leonberger puppy chest mass · congenital nerve sheath tumor in dogs · dog tumor biopsy results
Abstract
A 5-wk-old, 10.6-kg, intact female Leonberger dog was presented for evaluation of a mass on the left ventrolateral thorax that had been present since birth. A biopsy of the mass revealed an invasive, unencapsulated spindle-cell population arranged in bundles and concentric whorls (pseudo-onion bulb formations) with multifocal melanocytic differentiation. Neoplastic cells in pseudo-onion bulbs immunolabeled strongly for glial acidic fibrillary protein and PGP9.5 and moderately for S100 and Sox10. The supporting matrix had strong immunolabeling for laminin. Cells had multifocal immunolabeling for NeuN, melan A, and PNL2. Collectively, these histopathologic characteristics support a diagnosis of congenital nerve sheath tumor, which is rarely described in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41572669/