Peer-reviewed veterinary case report
Dog with blood clot caused by inherited protein C deficiency
By Kelly, Darren et al.·Published in Journal of veterinary internal medicine·2020·Southern Counties Veterinary Specialists, United Kingdom·View original on PubMed →
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Original publication title: Congenital protein C deficiency and thrombosis in a dog.
- Species:
- dog
Plain-English summary
A 4-year-old Hungarian Vizsla was brought to the vet because he suddenly developed fluid in his belly (ascites). Tests showed he had a large blood clot in his heart. After treatment with a medication called clopidogrel, his symptoms improved, but further testing revealed he had a rare genetic condition called congenital protein C deficiency, which can lead to blood clots. The vet switched his medication to rivaroxaban, and after six months, the dog was doing well with no signs of more clots.
People also search for: dog blood clot treatment · Hungarian Vizsla ascites · congenital protein C deficiency in dogs
Abstract
Congenital protein C deficiency is an important cause of thrombosis in humans but is not described in dogs. A 4-year-old Hungarian Vizsla was presented for investigation of acute onset of ascites. Computed tomography of the chest and abdomen and echocardiography confirmed a large thrombus within the right ventricle. A cause for thrombosis was not initially identified. The clinical signs resolved rapidly and the dog was administered clopidogrel and discharged. Plasma protein C activity measured 2 and 6 weeks later was markedly lower than expected on both occasions. All known causes of acquired protein C deficiency were excluded, and the dog was diagnosed with a congenital protein C deficiency. After diagnosis, the administration of clopidogrel was stopped and administration of rivaroxaban was started. The dog remains well with no evidence of recurrent thrombosis with 6 months of follow-up.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32277743/