Peer-reviewed veterinary case report
Construction of swine-specific CpG motif enriched plasmid and the study of its immunostimulatory effects both in vitro and in vivo.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2012
- Authors:
- Guo, Xiaoyu et al.
- Affiliation:
- Institute of Animal Science · China
Abstract
A swine-specific CpG motif enriched plasmid (pUC18-CpG) was constructed in this study. Its immunostimulant property was tested in vitro via lymphocyte transformation assay using swine peripheral blood mononuclear cells (PBMCs). The recombinant plasmid showed higher Stimulation Index (SI) compared to the positive control (LPS). In a following animal experiment, pUC18-CpG was co-administered with a commercial swine FMD killed vaccine. Animals in the pUC18-CpG adjuvanted groups showed much higher antibody titers during the vaccination period.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22814086/