Peer-reviewed veterinary case report
Corneal invasion by hemangiosarcoma in a horse.
- Journal:
- Veterinary ophthalmology
- Year:
- 2011
- Authors:
- Pinn, Toby L et al.
- Affiliation:
- Cornell University · United States
- Species:
- horse
Plain-English summary
A 15-year-old gray Arabian gelding was brought in because of a mass on the side of his eye that covered about 30% of his cornea. The mass was raised, smooth, and had some dead tissue in the center, along with some bloody fluid coming from it. The mass was surgically removed, and tests showed it was hemangiosarcoma, a type of cancer that affects blood vessels. Interestingly, the tests also revealed some unusual features that haven't been seen in other horses with this type of cancer. After the surgery, the horse has been doing well and is still healthy 21 months later, which is longer than many other horses with similar conditions have survived.
Abstract
A 15-year-old gray Arabian gelding presented for evaluation of a lateral limbal mass extending across approximately 30% of the cornea. Grossly, the raised mass appeared nonpigmented, smooth, and irregular in shape, with an area of central necrosis and serosanguinous discharge. The mass was removed via lamellar keratectomy and histopathologic evaluation revealed features characteristic of hemangiosarcoma (HSA), including irregular vascular channels lined by a plump spindle cell population. Immunohistochemistry results showed that the neoplastic cells lining the vascular channels present diffuse and strong cytoplasmic reaction with von Willebrand Factor and the perivascular spindle cells exhibit moderate cytoplasmic reaction for smooth muscle actin. A lack of cytokeratin staining definitively excluded a diagnosis of atypical squamous cell carcinoma. Smooth muscle actin staining of the perivascular cells adjacent to the neoplastic endothelial cells is not a feature commonly described in HSA and has not been reported in previous cases of equine HSA. The horse remained in good health 21 months postkeratectomy and has exceeded the survival time of previously documented equine ocular HSA cases where more extreme surgical excision was performed.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21521445/