Peer-reviewed veterinary case report
Accuracy of bone cytology compared to biopsy in diagnosing dog bone
By Berzina, Inese et al.·Published in Veterinary clinical pathology·2008·Department of Veterinary Population Medicine, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Correlation between cytologic and histopathologic diagnoses of bone lesions in dogs: a study of the diagnostic accuracy of bone cytology.
- Species:
- dog
Plain-English summary
A dog with a bone lesion underwent a cytology test (a method to examine cells) and later had a biopsy to confirm the diagnosis. The study found that cytology was quite accurate for identifying cancerous lesions, agreeing with biopsy results 92% of the time, while it was less reliable for non-cancerous conditions, with only 27% agreement. Additionally, samples with more cells showed better correlation with biopsy results. This means that if your dog has a bone issue and the cytology shows cancer, it’s likely to be accurate, but if it shows something non-cancerous, further testing may be needed for confirmation.
People also search for: dog bone cancer diagnosis · cytology vs biopsy for dog · dog bone lesion treatment
Abstract
BACKGROUND: The diagnostic value of cytology compared with histopathology varies by tissue, but there is little information regarding this comparison involving canine bone. OBJECTIVES: The objective of this retrospective study was to compare primary pathologic processes for cytology and histopathology of canine bone lesions. We adopted a proposed standardized format for reporting studies of diagnostic accuracy. METHODS: A computer search of canine medical records at the University of Minnesota Veterinary Medical Center from September 2002 through October 2006 identified 52 bone cytology samples that had incisional (IncB) and/or excisional (ExcB) biopsy performed. The primary pathologic process was determined by evaluation of original reports. Cytologic vs IncB and cytologic vs ExcB were compared pairwise for agreement. Agreement was compared for neoplastic and non-neoplastic processes using the combined IncB/ExcB data, which included all ExcB (n=21) and IncB when that was the only biopsy available (n=31). Combined data were used to determine the effect of cytology cellularity on the diagnostic correlation. RESULTS: The correlation in primary process between cytology and IncB was 71%, and for ExcB was 71%. For lesions with a cytologic diagnosis of neoplasia compared with the combined IncB/ExcB data set, cytology and histopathology agreed in 92% of cases, which was significantly greater (P<.0001, chi2) than the 27% for non-neoplastic processes. Cytology cellularity significantly affected rates of correlation (P=.026), with high, moderate, and poor cellularity samples having concordant primary processes in 88%, 77%, and 47% of cases, respectively. CONCLUSIONS: Cytologic diagnosis of neoplasia for samples collected from canine bone correlates better with histopathology than cytologic diagnosis of non-neoplastic proliferative processes or inflammation. Cytologic diagnoses from highly cellular samples are more likely to correlate with histopathology than those from less cellular samples.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18761529/