Peer-reviewed veterinary case report
Urine protein patterns linked to kidney damage severity in dogs
By Hokamp, Jessica A et al.·Published in Veterinary clinical pathology·2018·Department of Veterinary Pathobiology, United States·View original on PubMed →
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Original publication title: Correlation of electrophoretic urine protein banding patterns with severity of renal damage in dogs with proteinuric chronic kidney disease.
- Species:
- dog
Plain-English summary
A study looked at how urine protein patterns can help diagnose kidney damage in dogs with chronic kidney disease (CKD). Researchers found that these patterns were very accurate in identifying both glomerular (the filtering part of the kidney) and tubulointerstitial (the tissue surrounding the filtering units) damage. Specifically, the banding patterns were 97% effective for glomerular damage and 90% for tubulointerstitial damage. This means that veterinarians can use urine tests to better understand the severity of kidney issues in dogs with CKD, helping them choose the right treatment.
People also search for: dog kidney disease symptoms · protein in dog urine treatment · chronic kidney disease in dogs diagnosis
Abstract
BACKGROUND: Urine protein loss is common in dogs with chronic kidney disease (CKD). Currently available noninvasive means of evaluating CKD in dogs cannot accurately predict the severity of glomerular and tubulointerstitial damage. Electrophoretic analysis of urine proteins can indicate the compromised renal compartment (glomerular vs tubular), but extensive evaluation of protein banding pattern associations with histologic damage severity has not been performed in dogs. OBJECTIVES: We aimed to evaluate electrophoretic banding patterns as indicators of the presence and severity of glomerular and tubulointerstitial damage in dogs with naturally occurring, predominantly proteinuric CKD. METHODS: We performed a retrospective study using urine and renal tissue from 207 dogs with CKD. Urine protein banding patterns were correlated with histologic severity of renal damage. Sensitivity and specificity of banding patterns for the detection of glomerular and tubulointerstitial damage were determined. RESULTS: Banding patterns were 97% sensitive and 100% specific for the detection of glomerular damage and 90% sensitive and 100% specific for the detection of tubulointerstitial damage. Correlations between composite banding patterns and the severity of renal damage were strong, while glomerular banding patterns correlated moderately with glomerular damage severity, and tubular gel scores correlated weakly to moderately with the severity of tubulointerstitial damage. CONCLUSIONS AND CLINICAL IMPORTANCE: Urine protein banding patterns are useful for the detection of glomerular and tubulointerstitial damage in dogs with proteinuric CKD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30125968/