Peer-reviewed veterinary case report
How blood clot tests predict bleeding in dogs
By Enk, Nathalie M et al.·Published in Journal of veterinary internal medicine·2019·Department for Small Animals·View original on PubMed →
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Original publication title: Correlation of plasma coagulation tests and fibrinogenwith rotational thromboelastometry parameters and prediction of bleeding in dogs.
- Species:
- dog
Plain-English summary
A group of 97 dogs was studied to see how well certain blood tests could predict bleeding problems. The researchers found that a specific test measuring fibrinogen (a protein important for blood clotting) was strongly linked to how well blood clotted in other tests. They discovered that if the clotting time was longer than 149 seconds, it was a reliable indicator that the dog might be bleeding. This information can help veterinarians assess bleeding risks in dogs more effectively.
People also search for: dog bleeding symptoms · dog blood test results explained · how to tell if my dog is bleeding
Abstract
BACKGROUND: Correlation of plasma fibrinogen concentration (fibrinogen) with rotational thromboelastometry (ROTEM) parameters has not been investigated in dogs. OBJECTIVES: To determine the correlation between plasma coagulation tests and fibrinogenwith ROTEM parameters and to evaluate their ability to predict bleeding in dogs. ANIMALS: Ninety-seven dogs with concurrent determination of fibrinogenand fibrin polymerization test (FIBTEM) analysis. METHODS: Signalment, pretreatment, clinical signs of bleeding, fibrinogen, plasma coagulation test results, hematocrit, platelet count, FIBTEM, extrinsic (EXTEM) and intrinsic (INTEM) activated ROTEM assays were retrieved retrospectively. Correlations between fibrinogenand FIBTEM maximum clot firmness (MCF) and between prothrombin time (PT) or activated partial thromboplastin time (aPTT) and ROTEM parameters were determined. Dogs were further assigned to groups with or without clinical signs of bleeding. The prognostic significance of significantly different parameters to predict bleeding was evaluated. RESULTS: Fibrinogenshowed strong correlation with MCF(r = 0.860, n = 97, P < .001). PT showed strong correlation with EXTEM clotting time (CT) (r = 0.839, n = 53, P < .001), and aPTT was strongly correlated with INTEM CT (CT) (r = 0.664, n = 31, P < .001). Platelet count, PT/aPTT, EXTEM clot formation time (CFT), MCF, EXTEM maximum clot elasticity (MCE), and CTwere significantly different between groups. A CT>149 seconds was 100% sensitive to detect bleeding. CONCLUSIONS AND CLINICAL IMPORTANCE: The MCFcan be used to evaluate the effect of fibrinogen on hemostasis as an alternative to determination of fibrinogen. In addition, CTand CTare strongly correlated with PT and aPTT, respectively.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30537199/