Peer-reviewed veterinary case report
Dog skin melanoma tumor with muscle-like cancer cells
By Ramírez-Romero, Rafael·Published in Journal of comparative pathology·2025·Universidad Autó·View original on PubMed →
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Original publication title: Cutaneous melanoma with heterologous rhabdomyosarcomatous component in a dog.
- Species:
- dog
Plain-English summary
A dog was diagnosed with a rare type of skin tumor called cutaneous melanoma that also had a component resembling striated muscle. This unusual tumor contained very few pigment-producing cells and was a mix of different cell types, making it challenging to identify. The tumor was examined using special tests that showed the muscle fibers were well-developed and distinct from the melanoma cells. This case is significant because it is the first of its kind reported in dogs, highlighting the complexity of skin tumors in pets.
People also search for: dog skin tumor treatment · melanoma in dogs · unusual dog tumors · dog cancer symptoms · cutaneous melanoma in dogs
Abstract
Melanocyte-derived tumours are frequent in humans and animals and the clinicopathological progression of malignant presentations in dogs is comparable with humans. However, melanocytic tumours are a heterogeneous group of neoplasms with certain morphopathological patterns that may appear completely distant from the expected origin. Biphasic neoplasms with heterologous components representing transdifferentiation are uncommon and represent a challenge in diagnosis. Primary cutaneous melanomas with rhabdomyoblastic elements occur in humans but not in animals. We now describe a spontaneous case of cutaneous melanoma with rhabdomyosarcomatous component in a dog. A striated muscle heterologous component and dispersed cells with scarce melanin were interspersed in many regions of the neoplasm. The proportion of discrete melanocytic cells synthesizing scarce melanin was very low. The heterologous rhabdomyosarcomatous component contained well-differentiated striated muscle fibres, indicating that it was not rhabdoid. The muscle fibres were strongly immunoreactive for desmin, whereas the melanocytic component was diffusely, moderately immunopositive for Melan A, HMB45 and S100. To the author's knowledge, this is the first reported case of cutaneous melanoma with rhabdomyosarcomatous heterologous component in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40381375/