Peer-reviewed veterinary case report
Dog with multiple skin tumors and heart tumor like neurofibromatosis
By Castiglioni, Vittoria et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2022·Idexx Laboratories Italia, Italy·View original on PubMed →
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Original publication title: Cutaneous spindle cell tumors with features of peripheral nerve sheath tumors and concurrent cardiac involvement: neurofibromatosis type 1-like presentation in a Labrador Retriever dog.
- Species:
- dog
Plain-English summary
An 8-year-old male Labrador Retriever developed multiple skin lumps all over his body. These lumps were found to be tumors that originated from nerve tissue, and during a postmortem exam, a similar tumor was discovered in his heart. Unfortunately, the dog's health worsened, and he was euthanized due to his deteriorating condition. This case is unique because it involved both skin and heart tumors that had similar characteristics, which has not been reported in dogs before.
People also search for: dog skin lumps · Labrador Retriever heart tumor · dog euthanasia due to cancer · peripheral nerve sheath tumors in dogs
Abstract
An 8-y-old intact male Labrador Retriever dog developed cutaneous masses over the entire body. On histologic evaluation, the masses were composed of bundles of fusiform neoplastic cells arranged around adnexa, with mild atypia and no mitoses, consistent with peripheral nerve sheath tumors (PNSTs). Immunohistochemically, neoplastic cells were immunoreactive for vimentin, glial fibrillary acidic protein (GFAP), and S100, confirming their perineurial origin. The dog was euthanized because of deteriorating clinical signs. In addition to the cutaneous masses, a cardiac mass was identified at postmortem examination. The histopathologic and immunohistochemical features of the cardiac mass were similar to those of the cutaneous masses. To our knowledge, the combination of multiple cutaneous masses with features of PNSTs and a concurrent cardiac lesion has not been reported previously in a dog. We suggest "neurofibromatosis type 1-like" presentation for this unique combination of cutaneous and cardiac masses. Further studies are required to investigate the etiopathogenesis of this condition and explore its genetic background.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35291897/