Peer-reviewed veterinary case report
Cat with chronic ulcer on leg diagnosed with T-cell lymphoma
By Tobey, J C et al.·Published in Journal of the American Veterinary Medical Association·1994·Department of Veterinary Pathology, Canada·View original on PubMed →
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Original publication title: Cutaneous T-cell lymphoma in a cat.
- Species:
- cat
Plain-English summary
An 8-year-old male cat was taken to the vet because he had a long-lasting, non-healing sore on his left back leg. After examining the sore, the vet diagnosed it as cutaneous T-cell lymphoma, a type of skin cancer. Tests showed that the cat did not have feline leukemia virus (FeLV), which is often linked to lymphoma in cats. The vet confirmed the diagnosis through specialized tests that looked for cancerous cells. Treatment options for this type of lymphoma can vary, and it's important to discuss the best approach with your veterinarian.
People also search for: cat skin cancer treatment · why does my cat have a sore on his leg · feline leukemia virus and lymphoma
Abstract
An 8-year-old castrated male cat was examined because of a chronic, nonhealing, ulcerative lesion on the left hind limb. Cutaneous lymphoma was diagnosed on the basis of the morphologic appearance of malignant cells and Pautrier's microabscesses on light and electron microscopic examination. The tumor was found to be of T-cell origin by use of a polyclonal antibody recognizing T-cell antigen. Results of serum ELISA for FeLV were negative. The gp70 antigen of FeLV was not detected immunohistochemically in tumor tissue sections, using polyclonal goat antisera and avidin/biotin/peroxidase complex technique. Presence of FeLV was demonstrated by the polymerase chain reaction procedure, involving amplification of a 166-base pair region of FeLV DNA. Although FeLV is reported to be the cause of most types of lymphoma in cats, cats with epitheliotropic cutaneous lymphoma have consistently negative test results for circulating FeLV antigen. In such cases, using the polymerase chain reaction method, tumor DNA may be assessed for integrated FeLV provirus and the presence of FeLV can be confirmed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8163416/