Peer-reviewed veterinary case report
Early kidney function tests for critically ill dogs using Cystatin C
By Paes-Leme, Fabiola de Oliveira et al.·Published in Frontiers in veterinary science·2021·Department of Clinic and Surgery, Brazil·View original on PubMed →
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Original publication title: Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog.
- Species:
- dog
Plain-English summary
A group of critically ill dogs in the Intensive Care Unit was monitored for signs of acute kidney injury (AKI), a common complication in such cases. Researchers found that measuring a protein called cystatin C (CysC) in the blood was more effective for early detection of kidney problems than traditional methods like checking creatinine levels. Out of the 28 dogs studied, about 68% showed signs of AKI based on standard criteria, but this number increased to nearly 79% when using cystatin C. This suggests that testing for cystatin C could help veterinarians identify kidney issues sooner, allowing for better treatment options.
People also search for: dog kidney injury symptoms · acute kidney injury treatment in dogs · cystatin C test for dogs
Abstract
Critically ill hospitalized dogs are subject to certain complications, being acute kidney injury (AKI) a common one. Early diagnosis is crucial, and Cystatin C (CysC) is a reliable and early biomarker. The International Society of Renal Interest (IRIS) states that AKI severity can be assessed by mild changes in creatinine serum levels or reduction of urine output that cannot be considered biomarkers of renal injury but failure or insufficiency. Twenty-eight dogs admitted to the Intensive Care Unit under risk factors for the development of AKI were evaluated. Blood samples were collected for determination of sCr and CysC at admission and after 24, 48, and 72 h. Urine output was measured by daily monitoring, measured by collection in a closed system. The results showed the incidence of AKI was 67.9% based on the IRIS criteria and 78.6% based on cystatin C in critically ill patients' dogs. The measurement of serum cystatin C immediately on admission to the ICU was superior in the early identification of patients with AKI when compared to the IRIS classification and serum creatinine in critically ill dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34820434/