Peer-reviewed veterinary case report
Dog with uterine cysts and infection after long medroxyprogesterone
By Kim, Kyung-Suk & Kim, Okjin·Published in Journal of veterinary science·2005·NY Animal Hospital, South Korea·View original on PubMed →
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Original publication title: Cystic endometrial hyperplasia and endometritis in a dog following prolonged treatment of medroxyprogesterone acetate.
- Species:
- dog
Plain-English summary
An 8-year-old female Yorkshire Terrier was brought in because she had a reduced appetite and was occasionally vomiting. She had been receiving a hormone treatment called medroxyprogesterone acetate (MPA) for contraception since she was 3 years old. An ultrasound revealed that her uterus was abnormally enlarged, leading to surgery where the uterus and ovaries were removed. The examination showed that she had cystic endometrial hyperplasia (a thickening of the uterine lining) and endometritis (inflammation of the uterus), likely caused by the long-term use of MPA.
People also search for: dog vomiting and not eating · Yorkshire Terrier hormone treatment side effects · cystic endometrial hyperplasia in dogs
Abstract
An 8-year-old female Yorkshire Terrier was presented for investigation of reduced appetite, and occasional vomiting. She has been treated with medroxyprogesterone acetate (MPA) from past 3 year-old age for contraception. Abdominal sonography showed abnormal enlargement of uterus, and ovariohysterectomy was performed. Main gross findings of uterus were enlarged lesions in two areas of the left horn, which had thickened wall and yellowish sticky material in the lumen. Histopathologically, cystic endometrial hyperplasia (CEH) and endometritis were present in the thickened area. In this case, CEH and endometritis may be attributed to prolonged treatment of MPA. It was concluded that further study is needed to clarify the association of MPA treatment with age, its pathogenesis and abnormal uterine changes in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15785129/