Peer-reviewed veterinary case report
Cystic endometrial hyperplasia and endometritis in a dog following prolonged treatment of medroxyprogesterone acetate.
- Journal:
- Journal of veterinary science
- Year:
- 2005
- Authors:
- Kim, Kyung-Suk & Kim, Okjin
- Affiliation:
- NY Animal Hospital · South Korea
- Species:
- dog
Plain-English summary
An 8-year-old female Yorkshire Terrier was brought to the vet because she was eating less than usual and sometimes vomiting. She had been receiving a hormone treatment called medroxyprogesterone acetate (MPA) for birth control since she was 3 years old. An ultrasound of her abdomen showed that her uterus was abnormally enlarged, and surgery was performed to remove it. During the surgery, the vet found thickened areas in the uterus with yellowish sticky material, which were diagnosed as cystic endometrial hyperplasia (a condition where the uterine lining becomes thick and cystic) and endometritis (inflammation of the uterus). The findings suggest that the long-term use of MPA may have caused these issues, and more research is needed to understand how this treatment affects older dogs.
Abstract
An 8-year-old female Yorkshire Terrier was presented for investigation of reduced appetite, and occasional vomiting. She has been treated with medroxyprogesterone acetate (MPA) from past 3 year-old age for contraception. Abdominal sonography showed abnormal enlargement of uterus, and ovariohysterectomy was performed. Main gross findings of uterus were enlarged lesions in two areas of the left horn, which had thickened wall and yellowish sticky material in the lumen. Histopathologically, cystic endometrial hyperplasia (CEH) and endometritis were present in the thickened area. In this case, CEH and endometritis may be attributed to prolonged treatment of MPA. It was concluded that further study is needed to clarify the association of MPA treatment with age, its pathogenesis and abnormal uterine changes in dogs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15785129/