Peer-reviewed veterinary case report
Signs and diagnosis of brain tumors causing seizures in dogs
By Talavera, Michael et al.·Published in Veterinary clinical pathology·2025·Department of Pathobiology and Population Medicine and Clinical Sciences, United States·View original on PubMed →
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Original publication title: Cytologic and Histologic Features of Oligodendrogliomas in Three Dogs.
- Species:
- dog
Plain-English summary
Three dogs with chronic seizures were diagnosed with oligodendrogliomas, a type of brain tumor. They underwent MRI scans that showed abnormal masses in the brain, and during surgery, doctors used special stains to identify the tumor cells. The findings confirmed the presence of oligodendrogliomas in two of the dogs, while the third had an undefined tumor type. All dogs showed strong reactions to specific tests that helped confirm the diagnosis. Treatment details are not provided, but identifying the tumor type is crucial for planning further care.
People also search for: dog seizures causes · brain tumor in dogs treatment · oligodendroglioma in dogs symptoms
Abstract
To the authors' knowledge, this is the first canine oligodendroglioma case series to document the high-field magnetic resonance imaging (MRI) findings along with Wright-Giemsa stained intraoperative cytology findings, coupled with H&E and immunohistochemistry, and interpreted under the 2018 Comparative Brain Tumor Consortium (CBTC) criteria. All dogs in this case series presented with a history of chronic seizures. MRI findings for all cranial masses were T1 hypointense to isointense (Case 3) and T2 hyperintense. Cytologic characteristics of all cases included neoplastic cells haphazardly arranged in aggregates, embedded in an extracellular pink fibrillar to mucoid appearing matrix, and often associated with capillaries. Histologically, Case 1 (high-grade) and 3 (low-grade) had an oligodendroglioma morphology, while Case 2 had an undefined morphology. All cases were strongly immunoreactive to Olig2. Cases 1 and 2 were strongly immunoreactive to CNPase and had robust immunoreactivity to GFAP. This case series highlights that Wright-Giemsa intra-operative squash preparations stain can support a presumptive diagnosis of oligodendroglioma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41644271/