Peer-reviewed veterinary case report
Cytology of rare brown fat tumors in two dogs
By Piccione, Julie & Dial, Sharon M.·Published in Veterinary Clinical Pathology·2020·Texas A&M Veterinary Medical Diagnostic Laboratory (TVMDL) College Station TX USA, United States·View original on Crossref →
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Original publication title: Cytologic appearance of hibernoma in two dogs
- Species:
- dog
Plain-English summary
A 5-year-old male Labrador was brought in with unusual swelling around his eye. After examining the cells from the swelling, the vet suspected a rare type of tumor called a hibernoma, which is made up of brown fat. A biopsy confirmed the diagnosis, and the vet noted that the tumor cells had a unique appearance with many vacuoles. Fortunately, the tumor was benign, and the dog was treated successfully.
People also search for: dog eye swelling · hibernoma in dogs · Labrador tumor treatment · benign tumors in dogs · dog biopsy results
Abstract
AbstractHibernomas are rare benign tumors of brown fat (adipose tissue) that have been reported in several different species. The cytologic characterization of these tumors has not been described in dogs. In this case report, we describe two dogs with hibernomas, focusing on the cytologic appearance of these unique neoplasms. Both cytologic specimens were highly cellular and predominated by vacuolated neoplastic cells with no evidence of concurrent inflammation. The cells contained a moderate to large number of variably sized cytoplasmic vacuoles, with occasional, irregularly shaped pink granular material. Most cells contained a single nucleus; however, cells displayed moderate anisokaryosis. A biopsy with histologic examination was performed in both cases, confirming the cytologic suspicion of hibernoma. Immunohistochemistry revealed that both tumors were positive for UCP1 and vimentin, and negative for cytokeratin. Hibernoma is an important differential diagnosis in dogs with conjunctival and periocular swellings that exfoliate numerous, mildly atypical, vacuolated cells.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vcp.12836