Peer-reviewed veterinary case report
Cat with liver lymphoma invading liver cells diagnosed by cytology
By Finsterhölzl, Alina et al.·Published in Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·2023·Klinikum Veterinä·View original on PubMed →
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Original publication title: [Cytologic evidence of hepatocytotropic T-cell-lymphoma in a 15-year-old male cat].
- Species:
- cat
Plain-English summary
A 15-year-old male European Shorthair cat was brought in because he was not eating and was losing weight. Tests revealed that he had a rare type of liver cancer called hepatocytotropic T-cell lymphoma, where cancerous cells invade liver cells. The cat was treated with a steroid called prednisolone for two weeks, but unfortunately, his condition did not improve, and he was euthanized due to his poor health. A post-mortem examination confirmed the diagnosis of lymphoma.
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Abstract
This case report describes the rare phenomenon of emperipolesis-like invasion of lymphatic blasts into the hepatocytes of a 15-year-old European Shorthair cat. The cat presented with nonspecific clinical signs (inappetence and weight loss). Cytologic examination of an ultrasound-guided fine-needle aspirate of the liver showed a subset of hepatocytes with emperipolesis-like invasion by lymphatic blasts. Few extracellularly located lymphatic blasts exhibited erythrophagia. Following the cytological diagnosis of large cell lymphoma and 2 weeks of monotherapy with prednisolone, the patient was euthanized due to his poor general condition. A post-mortem sample was obtained from the liver to confirm the suspected cytological diagnosis of hepatocytotropic lymphoma. Histopathology subsequently confirmed the cytologic findings. Immunohistochemically, the lymphatic blasts were positive for CD3 leading to a diagnosis of hepatocytotropic T-cell-lymphoma, which has rarely been described so far.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38056480/