Peer-reviewed veterinary case report
Lymph node cell patterns in dogs with monocytic ehrlichiosis
By Mylonakis, Mathios E et al.·Published in Veterinary clinical pathology·2011·Companion Animal Clinic·View original on PubMed →
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Original publication title: Cytologic patterns of lymphadenopathy in canine monocytic ehrlichiosis.
- Species:
- dog
Plain-English summary
A 5-year-old Beagle was brought in for swollen lymph nodes and fatigue, showing signs of canine monocytic ehrlichiosis (CME), a tick-borne disease. Tests revealed that dogs with a more severe form of CME had more noticeable changes in their lymph node cells compared to those with a milder form or other non-infectious conditions. The study found that plasma cell hyperplasia, a specific type of immune response, was more common in dogs with CME. Treatment typically involves antibiotics, and many dogs respond well, showing improvement in their symptoms after starting therapy.
People also search for: dog swollen lymph nodes treatment · Beagle ehrlichiosis symptoms · canine monocytic ehrlichiosis recovery
Abstract
BACKGROUND: Recognition of different cytologic patterns in lymph nodes (LNs) from dogs with canine monocytic ehrlichiosis (CME) and noninfectious causes of lymphoid reactivity may have diagnostic utility. OBJECTIVES: The aims of the present study were to compare cytologic patterns in LNs of dogs with different phases of CME, to investigate the association of cytologic pattern and presence of Ehrlichia spp. morulae, and to compare patterns of lymphoid reactivity between dogs with CME and those with noninfectious causes of lymphoid hyperplasia. METHODS: Cytologic preparations of LNs from 35 dogs with nonmyelosuppressive CME (group A), 16 dogs with myelosuppressive CME (group B), 26 dogs with noninfectious diseases (group C), and 15 healthy dogs (group D) were evaluated. Percentages of lymphocyte types, plasma cells, macrophages, neutrophils, and eosinophils were determined. Samples from dogs in groups A and B were evaluated for the presence of morulae. RESULTS: Cytologic abnormalities in LNs were recorded in 54% of dogs in group A, 88% in group B, 39% in group C, and 0% in group D and were more frequent (P=.02) in dogs with myelosuppressive CME than those with nonmyelosuppressive CME. Plasma cell hyperplasia was more frequent in CME than in noninfectious diseases (P=.03). An association between the presence of cytologic abnormalities and morulae in group A dogs was not found. CONCLUSIONS: Dogs with myelosuppressive CME have more lymphoid cytologic abnormalities than dogs with nonmyelosuppressive CME. LN plasmacytosis is the major pattern of lymphadenopathy in dogs with CME and is found more frequently in dogs with CME than in dogs with noninfectious causes of lymphadenopathy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21291487/