Peer-reviewed veterinary case report
Brazilian propolis kills canine bone cancer cells in lab tests
By Cinegaglia, N C et al.·Published in Phytotherapy research : PTR·2013·Department of Microbiology and Immunology, Brazil·View original on PubMed →
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Original publication title: Cytotoxic action of Brazilian propolis in vitro on canine osteosarcoma cells.
- Species:
- dog
Plain-English summary
A study found that Brazilian propolis, a natural substance, showed promise in killing cancer cells from a dog with osteosarcoma (a type of bone cancer). The researchers tested how well propolis worked against these cancer cells over different time periods and found that it was effective in a dose-dependent manner, meaning higher amounts worked better. Importantly, the solvent used to dissolve the propolis did not affect the cancer cells, indicating that the propolis itself was responsible for the cancer-fighting action. This suggests that propolis could be explored as a potential treatment option for dogs with osteosarcoma in the future.
People also search for: dog osteosarcoma treatment · propolis for dog cancer · natural remedies for dog tumors
Abstract
Osteosarcoma (OSA) is a primary bone neoplasm frequently diagnosed in dogs. The biology of OSA in pet dogs is identical to that of pediatric patients, and it has been considered an excellent model in vivo to study human OSA. Since the individual response to chemotherapy is unpredictable and considering that propolis is a natural product with several biological properties, this work evaluated the cytotoxic action of propolis on canine OSA cells. The primary cell culture of canine OSA was obtained from the tumor of a dog with OSA. Cell viability was assessed after incubation with propolis, 70% ethanol (propolis solvent), and carboplatin after 6, 24, 48, and 72 h. Cell viability was analyzed by the crystal violet method. Data showed that canine OSA cells were sensitive to propolis in a dose- and time-dependent manner and had a distinct morphology compared to control. Its solvent (70% ethanol) had no effect on cell viability, suggesting that the cytotoxic action was exclusively due to propolis. Our propolis sample exerted a cytotoxic effect on canine OSA cells, and its introduction as a possible therapeutic agent in vivo could be investigated, providing a new contribution to OSA treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23074147/