Deep Fungal Infection of the Skin with Two Rare Fungi in a Dog Being Treated with Immunosuppressant Therapy: A Case Report

Abstract

Deep fungal skin infections in dogs being treated with immunosuppressant therapy pose a clinical challenge, balancing effective antifungal therapy with a sufficient immune function to control the infection whilst maintaining good control over the original disease. This case report describes the clinical presentation, diagnosis, and outcome of a dog with a concurrent deep fungal infection of the skin with two rare fungi, <i>Purpureocillium sodanum</i> and <i>Alternaria rosae</i>, and this is the first time this agents has been described in veterinary medicine. Challenges included fungal infections at multiple sites and drug–drug interactions between necessary immunosuppressive therapy and antifungals. Persistent lesions and limited therapeutic success emphasise the need for clinicians’ awareness, early diagnosis, individualised case management, and advances in immunosuppressive protocols.