Peer-reviewed veterinary case report
Deoxysugars as antituberculars and alpha-mannosidase inhibitors.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2014
- Authors:
- Kashyap, Vivek et al.
- Affiliation:
- CSIR-Central Drug Research Institute · India
- Species:
- rodent
Abstract
A promising modified sugar molecule was identified which was active against multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited the growth of M. tuberculosis in mice, and targeted alpha-mannosidase as a competitive inhibitor with a Ki value of 353.9 μM.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24687500/