Peer-reviewed veterinary case report
Clinical signs and treatment outcomes of large granular lymphoma
By Krick, E L et al.·Published in Veterinary and comparative oncology·2008·Department of Clinical Studies, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Description of clinical and pathological findings, treatment and outcome of feline large granular lymphocyte lymphoma (1996-2004).
- Species:
- cat
Plain-English summary
A group of cats diagnosed with large granular lymphocyte (LGL) lymphoma showed symptoms like decreased appetite, weight loss, lethargy, and vomiting. After testing negative for feline leukemia and feline immunodeficiency viruses, 23 of these cats received chemotherapy. While one cat had a complete response and six had partial responses to the treatment, the overall survival time for treated cats was only about 57 days. Unfortunately, this type of lymphoma is not very responsive to chemotherapy and tends to have a poor outlook.
People also search for: cat lymphoma symptoms · feline chemotherapy response · why is my cat vomiting and losing weight
Abstract
Feline large granular lymphocyte (LGL) lymphoma is an uncommon, morphologically distinct variant of feline lymphoma. Limited information exists in the literature regarding pathological and immunohistochemical descriptions, clinical findings, treatment and survival times. The purpose of this study was to describe clinical features, treatment and outcome in feline LGL lymphoma. Medical records of 45 cats with LGL lymphoma were retrospectively evaluated. Decreased appetite/anorexia, weight loss, lethargy and vomiting were the most commonly reported clinical signs. All cats tested for feline leukaemia virus and feline immunodeficiency virus infection were negative. The mesenteric lymph nodes and small intestine were the most commonly affected organs. One complete response and six partial responses were noted in the 23 cats that received chemotherapy as their initial treatment. Median survival time for cats that were treated was 57 days. Based on these results, feline LGL lymphoma appears to be minimally responsive to chemotherapy and is associated with a grave prognosis.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19178669/