Peer-reviewed veterinary case report
Feline large granular lymphocyte lymphoma signs and outcomes in Italy
By Finotello, R. et al.·Published in Veterinary and Comparative Oncology·2017·Small Animal Teaching Hospital, School of Veterinary Sciences University of Liverpool Neston UK, United Kingdom·View original on Crossref →
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Original publication title: Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (SIONCOV) retrospective study
- Species:
- cat
Plain-English summary
A group of 109 cats diagnosed with a rare type of cancer called large granular lymphocyte (LGL) lymphoma were studied to understand their symptoms and treatment outcomes. Most of these cats showed signs of illness, such as anemia and elevated liver enzymes, and many had cancer cells in their blood. Treatments varied, including surgery, chemotherapy, and corticosteroids, but unfortunately, the average survival time was only about 21 days. A small number of cats did survive longer than six months, indicating that some may have a better chance with this condition.
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Abstract
Feline large granular lymphocyte (LGL) lymphoma is an uncommon subtype of lymphoma characterized by a grave prognosis and scarce response to chemotherapy. There are limited reports on clinico‐pathological and prognostic factors. One‐hundred and 9 cats with newly diagnosedLGLlymphoma that underwent initial staging (including hematology, serum biochemistry, thoracic radiographs and abdominal ultrasound), and followed‐up were retrospectively evaluated.LGLlymphoma was localized within the gastrointestinal tract with or without extra‐intestinal involvement in 91.7% of the cases, and at extra‐gastrointestinal sites in 8.3%. Symptoms were frequent. Anemia (31.2%) and neutrophilia (26.6%) were commonly observed, and 14 (12.8%) cats had neoplastic circulating cells. Frequent biochemistry abnormalities included elevatedALT(39.4%) and hypoalbuminemia (28.4%). Twenty (54.1%) of 37 cats had elevated serumLDH. Treatment varied among cats, and included surgery (11%), chemotherapy (23%), corticosteroids (38.5%) and no treatment (27.5%). Median time to progression (MTTP) was 5 days, and median survival time (MST) 21 days.MSTwas significantly shorter in the case of substage b, circulating neoplastic cells, lack of chemotherapy administration, and lack of treatment response. A small subset of cats (7.3%) survived more than 6 months, suggesting that a more favorable clinical course can be found amongLGLlymphoma patients.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vco.12325