Peer-reviewed veterinary case report
Design, synthesis and SAR of novel glucokinase activators.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2013
- Authors:
- Cheruvallath, Zacharia S et al.
- Affiliation:
- Takeda California · United States
Abstract
Guided by co-crystal structures of compounds 15, 22 and 30, an SBDD approach led to the discovery of the 6-methyl pyridone series as a novel class of GKAs that potently activate GK in enzyme and cell assays. Anti-diabetic OGTT efficacy was demonstrated with 54 in a mouse model of type 2 diabetes.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23434031/