Peer-reviewed veterinary case report
Canine parvovirus types and mutations found in Shandong dogs
By Li, Jiahui et al.·Published in Virus genes·2025·College of Veterinary Medicine, China·View original on PubMed →
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Original publication title: Detection and molecular epidemiology of canine parvovirus and identification of highly pathogenic CPV-2c isolates from Shandong, China.
- Species:
- dog
Plain-English summary
A group of dogs in Shandong, China, was found to be infected with a highly contagious virus called canine parvovirus (CPV), which can cause severe illness. Out of 62 sick dogs tested, nearly 63% were positive for the virus, with most cases linked to a dangerous subtype known as CPV-2c. This strain has mutations that could affect how it spreads and how well vaccines work against it. One specific strain was shown to be fatal in infected dogs during testing. Pet owners should be aware of the risks of parvovirus, especially in unvaccinated dogs.
People also search for: dog parvovirus symptoms · CPV-2c strain in dogs · canine parvovirus treatment · why is my dog vomiting and lethargic · dog vaccination importance
Abstract
Canine parvovirus (CPV) is an important pathogen of dogs and wild carnivores. It is a single-stranded DNA virus with a high mutation frequency and antigenic drift. To research the prevalence and genetic variation of CPV in Shandong, 62 samples from diseased dogs were collected and examined by using PCR for parvovirus. Our results showed that the positivity was 62.9% (n = 39), VP2 gene were sequenced and compared with reference strains. For the parvovirus subtype prevalence, 7 strains were CPV-2a (17.9%) and 32 strains were CPV-2c (82.1%). The results of phylogenetic analysis of VP2 gene of the CPVs showed all 39 isolates formed a major clade and were distantly related to the commercial vaccine strains. By comparing amino acid (aa) sequences, this study discovered new mutations not previously reported which may be related to host range and antigenicity. Moreover, one CPV-2c strain (QN-55) was isolated and cultured on F81 cells, and characterized by whole-genome sequencing. The TCIDof this strain was 10/0.1 mL and animal tests have shown that the strain is fatal to infected dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39625586/