Peer-reviewed veterinary case report
Detection and Whole-Genome Analysis of a High-Risk Clone ofST340/CG258 Producing CTX-M-15 in a Companion Animal.
- Journal:
- Microbial drug resistance (Larchmont, N.Y.)
- Year:
- 2020
- Authors:
- Valencia-Bacca, Juan et al.
- Affiliation:
- Department of Preventive Veterinary Medicine and Animal Health · Brazil
- Species:
- cat
Abstract
The emergence and dissemination of high-risk clones ofproducing extended-spectrum β-lactamases (ESBLs) in animal infections is a critical issue. We report the detection and genomic features of a multidrug-resistant (MDR) ESBL (CTX-M-15)-producinginfecting a domestic cat. Whole-genome sequencing analysis identified the international ST340 (clonal group CG258), and genes and mutations conferring resistance to β-lactams, aminoglycosides, macrolides, phenicols, fosfomycin, sulfonamides, tetracycline, trimethoprim, and fluoroquinolones. In addition, the presence of genes encoding resistance to disinfectant and heavy metals hazardous to humans was also confirmed. The MDR profile exhibited by the strain contributed to treatment failure and death of the companion animal. Therefore, active surveillance of critical priority lineages ofshould not only focus on human infections but also on veterinary infections.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31809242/