Peer-reviewed veterinary case report
Detecting anti-neutrophil antibodies in dogs with immune diseases
By Tamamoto, Takashi et al.·Published in Veterinary immunology and immunopathology·2018·Department of Small Animal Clinical Sciences, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Detection of anti-neutrophil cytoplasmic antibodies in dogs with immune-mediated inflammatory diseases.
- Species:
- dog
Plain-English summary
A group of 16 dogs with immune-mediated inflammatory diseases (IMIDs) were tested for a specific type of autoantibody called anti-neutrophil cytoplasmic antibodies (ANCA). The results showed that 81.3% of these dogs tested positive for ANCA, compared to only 28.03% of healthy dogs. This suggests that ANCA is more commonly found in dogs with IMIDs, indicating a possible link between the presence of these antibodies and the activation of immune responses in these diseases. Understanding ANCA positivity could help veterinarians diagnose and treat dogs with IMIDs more effectively.
People also search for: dog autoimmune disease symptoms · dog inflammatory bowel disease treatment · why is my dog sick with infections
Abstract
Anti-neutrophil cytoplasmic antibody (ANCA) is a type of autoantibody against neutrophil cytoplasm. In veterinary medicine, few studies have reported the detection of ANCA in dogs, and most of these studies were performed in dogs with inflammatory bowel disease (IBD). The aim of this study was to evaluate whether ANCA is detected in dogs with immune-mediated inflammatory diseases (IMIDs) other than IBD. Serum samples were collected before treatment initiation from 40 client-owned dogs with various diseases and 22 healthy beagle dogs; the dogs were classified into two groups: IMID group (n = 16) and control group (n = 46). ANCA was detected using the indirect fluorescent antibody test. Of the 16 dogs in the IMID group, 13 (81.3%) tested positive for ANCA. In contrast, of the 46 dogs in the control group, 13 (28.03%) tested positive for ANCA. Moreover, a significant association between ANCA positivity and IMIDs was identified in the IMID group than in the control group (P = 0.0003). In the control group, however, dogs with bacterial infection showed a relatively high rate of ANCA positivity. Therefore, ANCA positivity was observed in dogs with both IMIDs and bacterial infection. This suggested that ANCA positivity is associated with diseases accompanied by neutrophil activation and infiltration.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30243372/