Peer-reviewed veterinary case report
Ehrlichia, Babesia, and Toxoplasma DNA found in brains of dogs
By Cardinot, Cinthya B et al.·Published in The Journal of parasitology·2016·School of Veterinary Medicine, Brazil·View original on PubMed →
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Original publication title: Detection of Ehrlichia canis, Babesia vogeli, and Toxoplasma gondii DNA in the Brain of Dogs Naturally Infected with Leishmania infantum.
- Species:
- dog
Plain-English summary
A group of 24 dogs naturally infected with Leishmania infantum, a parasite that causes visceral leishmaniasis, were studied to see if they also had other infections. Among these dogs, 22 showed symptoms of illness, and 2 had neurological signs. Researchers found that 95.8% of the dogs had Leishmania DNA in their brain tissue, and many were also co-infected with other pathogens like Ehrlichia canis and Babesia vogeli. This study highlights the importance of testing for Leishmania in dogs with neurological issues, as it can affect the brain.
People also search for: dog brain infection symptoms · Leishmania treatment in dogs · Ehrlichia canis in dogs
Abstract
The aims of this study were to investigate the presence of Leishmania infantum and possible co-infection with Anaplasma platys , Babesia vogeli, Ehrlichia canis , and Toxoplasma gondii in the brain of 24 dogs naturally infected by L. infantum . A total of 24 mongrel adult dogs (22 clinically affected, 2 with neurological signs, and 2 subclinically infected) aged between 2 and 5 yr, naturally infected by visceral leishmaniasis, were selected. Fragments from meninges, frontal cortex, thalamus, cerebellum, and choroid plexus of the lateral ventricles and fourth ventricle were collected, mixed, and tested by real-time polymerase chain reaction (qPCR). Leishmania infantum DNA was detected in 95.8% (23/24) of the infected dogs, including the subclinically infected. A total of 14/24 (58.3%) dogs were co-infected by E. canis and L. infantum , 4/24 (16.7%) were co-infected by E. canis , B. vogeli, and L. infantum , 2/24 (8.3%) were co-infected by B. vogeli and L. infantum , and 1/24 (4.2%) dog was co-infected by E. canis , B. vogeli, T. gondii , and L. infantum . All 24 brain samples tested negative for A. platys . These results demonstrate that L. infantum is able to penetrate into the brain parenchyma, either alone or in association to other zoonotic pathogens. In addition, qPCR could be considered for adequate evaluation of Leishmania in the brain tissue of dogs with neurological signs that have died.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26765523/