Peer-reviewed veterinary case report
Leishmania infection and eye muscle inflammation in dogs
By Naranjo, Carolina et al.·Published in Veterinary ophthalmology·2010·Department of Pathobiological Sciences, United States·View original on PubMed →
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Original publication title: Detection of Leishmania spp. and associated inflammation in ocular-associated smooth and striated muscles in dogs with patent leishmaniosis.
- Species:
- dog
Plain-English summary
A group of dogs with leishmaniosis, a disease caused by a parasite, showed signs of inflammation in the muscles around their eyes. Inflammation was found in about 11% of smooth muscle samples and 25% of striated muscle samples, with the parasite detected in 9% of smooth muscles and nearly 20% of striated muscles. This inflammation could lead to symptoms like eyelid swelling, eye inflammation, and other eye problems. Understanding this connection can help veterinarians better diagnose and treat affected dogs.
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Abstract
OBJECTIVE: Canine leishmaniosis is a disease characterized by the wide distribution of the parasite throughout the tissues of the host. The purpose of this study was to describe the presence of Leishmania spp. and associated inflammation in ocular-associated muscles of dogs with patent leishmaniosis. PROCEDURES: Smooth muscles (iris dilator muscle, iris sphincter muscle, ciliary muscle, Müller muscle, smooth muscle of the periorbita and smooth muscle of the nictitating membrane) and striated muscles (orbicularis oculi muscle, obliquus dorsalis muscle and dorsal rectus muscle) were evaluated. Routine staining with hematoxylin and eosin and immunohistochemistry to detect Leishmania spp. were performed on tissue sections. RESULTS: Granulomatous inflammation was seen surrounding muscular fibers and was composed mainly of macrophages with scattered lymphocytes and plasma cells. This infiltrate could be seen in 52/473 (10.99%) samples of smooth muscle and 36/142 (25.35%) samples of striated muscle. Parasites were detected in 43/473 (9.09%) samples of smooth muscle and in 28/142 (19.71%) samples of striated muscle. CONCLUSIONS: To the authors' knowledge, this is the first report assessing the presence of Leishmania spp. and associated infiltrate in intraocular, extraocular and adnexal smooth and striated muscles. The inflammation present in those muscles could contribute to clinical signs already described, such as blepharitis, uveitis, and orbital cellulitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20500712/