Peer-reviewed veterinary case report
Dog developed liver cancer after long-term danazol treatment
By Kobayashi, Kosuke et al.·Published in The Journal of veterinary medical science·2016·Joint Faculty of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog.
- Species:
- dog
Plain-English summary
A 2-year-old female beagle was brought in for anemia, which is a condition where the dog has low red blood cells. After tests showed she had non-regenerative immune-mediated anemia (NRIMA), the vet started her on a combination of immunosuppressive medications. Initially, this treatment didn't work, but adding danazol helped improve her anemia. Unfortunately, about 20 months later, she developed liver cancer (hepatocellular carcinoma) as a possible side effect of the long-term use of danazol.
People also search for: dog anemia treatment · beagle liver cancer symptoms · danazol side effects in dogs
Abstract
A 2-year-old female beagle was referred to our hospital for evaluation of anemia. Laboratory tests, including bone marrow cytology, revealed non-regenerative immune-mediated anemia (NRIMA). Although initial immunosuppressive multi-drug therapy was not effective, additional administration of danazol was successful in treating the anemia. However, hepatocellular carcinoma (HCC) developed about 20 months after the administration of danazol. In humans, several cases of development of HCC after the administration of danazol have been reported. The present report describes a case of HCC development in a dog after chronic administration of danazol in addition to other immunosuppressive drugs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27320967/