Peer-reviewed veterinary case report
Dog with T-cell leukemia and B-cell lymphoma treated with chemo
By Okawa, Takumi et al.·Published in The Journal of veterinary medical science·2012·Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Development of high-grade B-cell lymphoma concurrent with T-cell chronic lymphocytic leukemia in a dog.
- Species:
- dog
Plain-English summary
A 10-year-old male golden retriever was brought in with swollen lymph nodes, which indicated he had high-grade B-cell lymphoma alongside T-cell chronic lymphocytic leukemia (CLL). Tests showed that the lymph nodes had large lymphocytes, confirming the lymphoma, while his blood had small lymphocytes typical of CLL. The dog was treated with a chemotherapy protocol that worked for about 155 days, but unfortunately, he passed away 194 days after his diagnosis despite additional treatments.
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Abstract
Second malignancies are frequent complications in human patients with chronic lymphocytic leukemia (CLL). However, the clinical details and outcome of this phenomenon were unclear in their canine counterparts. Here, we report a dog with high-grade lymphoma concurrent with T-cell CLL. A 10-year-old male golden retriever presented with lymphadenopathies. The lymph nodes contained large-sized lymphocytes, raising suspicion of high-grade lymphoma. Meanwhile, small lymphocytic lymphocytosis in the peripheral blood was consistent with CLL. Interestingly, molecular biological analyses revealed that CLL cells were of the T-cell type, whereas lymphoma cells were of the B-cell type. Chemotherapy using the L-VCA short protocol was effective for 155 days, but the dog died on day 194 after diagnosis, despite rescue therapies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22200671/